Prophylactic atropine administration prevents vasovagal response induced by cryoballoon ablation in patients with atrial fibrillation
10.3969/j.issn.1004-8812.2017.07.004
- VernacularTitle:预注射阿托品预防心房颤动冷冻球囊消融术中迷走反射
- Author:
Caihua SANG
;
Liping SUN
;
Jianzeng DONG
;
Rong BAI
;
Songnan LI
;
Deyong LONG
;
Ronghui YU
;
Ribo TANG
;
Chenxi JIANG
;
Nian LIU
;
Xueyuan GUO
;
Songnan WEN
;
Man NING
;
Xin DU
;
Changsheng MA
- Keywords:
Vasovagal response;
Atropine;
Atrial fibrillation;
Cryoballoon
- From:
Chinese Journal of Interventional Cardiology
2017;25(7):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective Cryoballoon ablation of pulmonary vein (PV) ostia often induces a vagal response.This prospective study was designed to assess the effectiveness of prophylactic intravenous administration of atropine on hemodynamic impairment induced by cryoballoon ablation in patients with atrial fibrillation.Methods Twenty-five patients with paroxysmal atrial fibrillation undergoing cryoballoon ablation were prospectively enrolled and assigned to either the trial group on the control group.First twelve patients (the trial group) were administered 1 mg of atropine before deflation of the cryoballoon,while the following 13 patients (the control group) were given atropine only after the onset of the hemodynamic variation (decrease in heart rate and/or blood pressure).Treatment was considered effective when the hemodynamic variations were restored.Results In the trial group,three patients with transient hypotension did not require further supportive care throughout the procedures and one patient with hypotension required supportive management.In the control group,hypotension,bradycardia and mixed bradycardia with hypotension requiring supportive care occurred in six,three,and three patients,respectively.Overall,the rate of marked vagal responses was significantly lower when prophylactic atropine was administrated (4/12 vs.12/13 patients,P ＜ 0.01).Conclusions Atropine is effective in the prevention of all types of vasovagal responses induced by cryoballoon ablation in patients with atrial fibrillation.
