Research progress of CTGF/CCN2 in the development and targeted therapy of malignant tumor
10.11904/j.issn.1002-3070.2017.04.014
- VernacularTitle:CTGF/CCN2在恶性肿瘤的发生发展及靶向治疗中的研究进展
- Author:
Yuqi SUN
- Keywords:
CTGF/CCN2 protein;
Structural function;
Malignancy;
Targeted therapy
- From:
Practical Oncology Journal
2017;31(4):363-366
- CountryChina
- Language:Chinese
-
Abstract:
The current incidence of malignant tumors is increasing.Although we have been exploring the mechanism of tumor development and its treatment,its efficacy is little.Malignant tumor development mechanism is very complex,and a variety of proteins and genes involved.Connective tissue growth factor(CTGF,also known as CCN2)is a secreted protein,a member of the CCN family,which plays a very important role in the development and progression of tumors.This article summarizes the structure and function of CTGF /CCN2 protein,the mechanism of action in the development of malignant tumors and the latest research progress in targeted therapy.
