Effects of valsartan and amlodipine on urinary microalbumin in elderly patients with hypertension
10.3969/j.issn.1005-1678.2017.08.054
- VernacularTitle:缬沙坦和左旋氨氯地平联用对老年高血压患者尿微量清蛋白的影响
- Author:
Jianmin SONG
;
Shengli HAN
;
Xue GONG
- Keywords:
stan;
amlodipine;
elderly hypertension;
microalbuminuria;
clinical impact
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):135-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of valsartan and amlodipine on urinary microalbumin in elderly hypertensive patients. Methods 100 elderly patients with hypertension treated in our hospital from May 2015 to October 2016 were selected and randomly divided into the control group and the experimental group, with 50 patients in each group. The patients in the control group received oral valsartan, and the patients in the experimental group were treated with valsartan and amlodipine. The treatment time of the experimental group and the control group was 12 weeks. The clinical indexes of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the experimental group and the control group did not have obvious adverse reactions. There were 2 cases of headache in the experimental group, 1 cases of vertigo, and 2 cases of vertigo in the control group. However, there was no significant difference in the incidence of adverse reactions between the experimental group and the control group, and there was no statistical significance. The antihypertensive effect of the experimental group was significantly higher than that of the control group, with statistical significance (P<0.05). After treatment, the urinary microalbumin in the experimental group and the control group was significantly lower than that in the treatment group, and the level of microalbuminuria in the experimental group was lower than that in the control group, with statistical significance (P<0.05). Conclusion The clinical effect of treatment of elderly patients with hypertension better combined with valsartan and amlodipine, antihypertensive effect is stronger, can significantly improve the patient's urinary albumin, with further clinical promotion and application significance.
