Effect of dexamethasone on the expression of ICH and APQ-4 in brain tissue of hematoma in rats
10.3969/j.issn.1005-1678.2017.08.002
- VernacularTitle:地塞米松对ICH实验大鼠血肿脑组织APQ-4及细胞因子表达的影响分析
- Author:
Wei WANG
;
Yibin HUANG
;
Fangyun ZHAO
- Keywords:
dexamethasone;
cerebral hemorrhage;
aquaporin-4;
tumor necrosis factor-ɑ
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexamethasone on the expression of APQ-4 and cytokines in the hematoma and brain tissue of ICH rats. Methods The treatment group was treated with injection of 1mg/kg and dexamethasone, and the model group and the sham operation group were injected with the same amount of normal saline. Results The model group APQ-4, TNF- positive cells. The proportion of second, third, the highest in the 7d after the operation, the sham operation group was the lowest (P<0.05). Conclusion Dexamethasone is beneficial to reduce the APQ-4 expression in brain tissue of rats in ICH, while reducing the expression of TNF- alpha.
