The Association of SNP on Chromosome 9p21 with Myocardial Infarction in Yunnan Yi nationality
10.3969/j.issn.1005-1678.2017.08.005
- VernacularTitle:染色体9p21基因多态性与云南彝族人群心肌梗死的相关性研究
- Author:
Lili LIU
;
Furong ZHANG
;
Liang HE
;
Ping LIU
;
Maiqiao YANG
;
Fang WANG
- Keywords:
myocardial infarction(MI);
chromosome 9p21;
single nucleotide polymorphism(SNP)
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between 9p21 single nucleotide polymorphism (SNP) and myocardial infarction(MI) in Yunnan Yi nationality. Methods One hundred and ten patients with MI and 110 controls were enrolled. DNA sequencing was used to detect 9p21 gene locus and SNP typing and analysis. Results Hardy-Weinberg equilibrium was found in 9 sites of chromosome 9p21 in myocardial infarction group and control group.The frequency of rs1333049 GG genotype was 30.91% and 18.18% in case group and control group respectively, G The frequencies of rs2383206 GG genotype were 31.82% and 18.18%, respectively, and the frequencies of G allele were 55.3% and 41.1%, respectively. There were significant differences between the two groups 58.3% and 44.9%, The difference between the two groups was statistically significant(P<0.05). Conclusion This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI in in Yunnan Yi nationality.
