Effect of warfarin combined with urokinase on prevention of deep venous thrombosis of lower extremity after hip replacement
10.3969/j.issn.1005-1678.2017.08.009
- VernacularTitle:华法林联合尿激酶预防髋关节置换术后下肢深静脉血栓形成的效果观察
- Author:
Yan WANG
;
Hui FAN
- Keywords:
Warfarin;
urokinase;
hip replacement;
lower extremity deep venous thrombosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of warfarin combined with urokinase in the prevention of deep venous thrombosis after hip replacement. Methods 58 patients undergoing hip replacement in our hospital from October 2014 to October 2016 were randomly divided into the observation group and the control group, 29 cases in each group. The control group were treated with oral warfarin, the observation group was treated with warfarin combined with urokinase, two groups of patients were treated for 14d, the incidence of lower limb deep vein thrombosis, follow-up statistics of two groups of patients within three months after operation, the diameter and blood rheology changes before and after weeks of treatment of lower extremity. Results During the treatment and follow-up of 14d patients in the control group, the incidence of deep venous thrombosis was 20.67% significantly higher than the observation group 3.45% (P<0.05); after treatment, the two groups of patients with lower limb circumference difference was significantly reduced (P<0.05), and the patients in the observation group the thigh circumference, calf circumference difference was significantly less than the control group (P<0.05); after treatment, the two groups of patients with high blood viscosity, low blood viscosity, plasma viscosity and hematocrit were significantly lower than those before treatment (P<0.05), and the indicators of the observation group were significantly lower than the control group (P<0.05). Conclusion Warfarin combined with urokinase can effectively prevent the formation of deep vein thrombosis of lower extremity after hip replacement, improve the hypercoagulability of patients and reduce the circumference of the lower extremity, so it is worthy of clinical application.
