Effects of Danqi Granules combined with Xianling Gubao Capsules on bone metabolism and bone mineral density in patients with postmenopausal osteoporotic vertebral compression fractures after surgery
10.3969/j.issn.1005-1678.2017.08.014
- VernacularTitle:丹杞颗粒联合仙灵骨葆胶囊对绝经后骨质疏松性椎体压缩骨折术后骨代谢、骨密度的影响
- Author:
Yusong CHEN
;
Xiaotao HUANG
;
Lve FANG
;
Jinjin LAO
;
Yekai DONG
- Keywords:
postmenopausal osteoporosis;
Danqi Granules;
Xianling Gubao capsules;
bone metabolism;
bone mineral density
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):33-34,37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Danqi Granules combined with Xianling Gubao Capsules on bone metabolism and bone mineral density (BMD) in patients with postmenopausal osteoporotic vertebral compression fractures (OVCF) after surgery. Methods 90 cases of postmenopausal women with OVCF were randomly divided into the control group and the observation group, 45 cases in each group. The two groups were treated by vertebroplasty (PVP), and after the surgery, the control group was treated with Xianling Gubao Capsules while the observation group was additionally given Danqi Granules. The serum markers of bone metabolism [(25 (OH) D, PINP, β-CTX] and BMD of L2-4 and left femoral neck were detected before and after treatment. Results The level of serum 25 (OH) D in the observation group after treatment was significantly higher while the levels of PINP and β-CTX were significantly lower than those in the control group (P<0.05), and the BMD of L2-4 and left femoral neck of the observation group were significantly higher than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Danqi Granules combined with Xianling Gubao Capsules can significantly accelerate fracture recovery, and improve bone mineral density in the treatment of postmenopausal women with OVCF.
