Comparison on the effect of two kinds of mucosal protective agents combined with smoking cessation on the treatment of peptic ulcer

VernacularTitle:两种黏膜保护剂合并戒烟对消化性溃疡的疗效比较
Author: Guangsheng LIU ; Fang XU ; Jianyong ZHOU ; Shengliang ZHOU
Keywords: mucosal protective agent; smoking cessation; peptic ulcer
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(8):88-90
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of two kinds of mucosal protective agents combined with smoking cessation on peptic ulcer. Methods In our hospital from January 2014 to December 2016, 244 cases with peptic ulcer with smoking as the research object, randomly divided into the control groupand the observation group, 122cases in each group. The control group were given omeprazole and smoking cessation and bismuth potassium citrate, the observation group were given omeprazole and smoking cessation and misoprostol. The therapeutic effect and adverse reaction were compared between the two groups. Results The total efficiency in the observation group 97.54% was significantly higher than the control group 87.70% (P<0.05). The incidence of adverse reactions in the observation group 2.46% was significantly lower than in the control group 7.38% (P<0.05). Conclusion For the treatment of refractory peptic ulcer with the habit of smoking, smoking cessation combined with Losec and misoprostol can effectively improve the effect, and reduce the occurrence of adverse reaction, which is worthy of promotion.