Application of zoledronic acid combined with psychological intervention in the treatment of osteoporotic vertebral compression fractures after PKP
10.3969/j.issn.1005-1678.2017.08.044
- VernacularTitle:唑来膦酸联合心理干预治疗骨质疏松性椎体压缩骨折PKP术后中应用研究
- Author:
Yu QIAN
;
Qingfeng WANG
;
Guohai FU
;
Weiwei SHAO
- Keywords:
zoledronic acid;
psychological intervention;
osteoporotic vertebral compression fractures;
PKP surgery
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of zoledronic acid combined with psychological intervention in osteoporotic vertebral compression fractures in percutaneous balloon kyphoplasty (PKP). Methods 72 patients with osteoporotic vertebral fractures underwent PKP operation from August 2013 to August 2015 were randomly divided into observation group and control group,with 36 cases,in each group. The patients in the control group were given salmon calcitonin after operation. The patients in the observation group were given zoledronic acid after operation. Both patients were given psychological care. The total effective rate of clinical treatment and the incidence of secondary osteoporotic vertebral compression fractures,Visual analogue pain scale before and after treatment (VAS), Oswestry dysfunction index questionnaire (ODI) score, bone mineral density T value changes were compared between the two groups. Results The total effective rate was 94.44% in the observation group and 77.78% in the control group (P<0.05). The recurrence fracture rate was significantly lower than that of the control group (P<0.05). After treatment, the scores of VAS and ODI in the observation group were significantly lower than those in the control group (P<0.05). The T value of bone mineral density was significantly higher than that of the control group (P<0.05). Conclusion Zoledronic acid combined with psychological intervention can effectively improve the effective rate of PKP after osteoporotic vertebral compression fractures, increase bone density and reduce the incidence of fracture, which is worthy of clinical application.
