Nutritional status, cachexia, and anorexia in women with peritoneal metastasis and intraperitoneal chemotherapy: a longitudinal analysis.
- Author:
Ziad HILAL
1
;
Günther A REZNICZEK
;
Robert KLENKE
;
Askin DOGAN
;
Clemens B TEMPFER
Author Information
- Publication Type:Original Article
- Keywords: Intraperitoneal; Ovarian Neoplasms; Nutrition; Aerosol; Palliative
- MeSH: Adipose Tissue; Anorexia*; Arm; Ascites; Body Mass Index; C-Reactive Protein; Cachexia*; Chemistry; Drug Therapy*; Electric Impedance; Fallopian Tubes; Female; Follow-Up Studies; Humans; Intra-Abdominal Fat; Karnofsky Performance Status; Leg; Metabolism; Muscle, Skeletal; Neoplasm Metastasis*; Nutrition Assessment; Nutritional Status*; Ovarian Neoplasms; Transferrin
- From:Journal of Gynecologic Oncology 2017;28(6):e80-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To describe the nutritional status of women with peritoneal metastasis (PM) from recurrent ovarian, fallopian, or peritoneal cancer and to assess longitudinal variations of the cachexia-anorexia syndrome (CAS) during palliative pressurized intraperitoneal aerosol chemotherapy (PIPAC). METHODS: Nutritional assessment included body mass index (BMI), bioelectrical impedance analysis (BIA), and blood chemistry. CAS presence/absence was recorded before and during repeated cycles (1–11) of PIPAC. RESULTS: Eighty-four patients with peritoneal cancer (n=5) or PM from recurrent ovarian (n=77) or fallopian tube (n=2) cancer were included. At baseline, resting metabolism (RM) (1,432±172 kcal/day), visceral fat level (7.5±3.2), skeletal muscle mass (27.2%±4.6%), upper arm circumference (27.9±4.6 cm), lower leg circumference (35.1±3.9 cm), serum parameters (albumin [3.5±0.7 g/dL], total protein [6.3±0.9 g/dL], and transferrin [202±60 mg/dL]) were below normal limits. C-reactive protein (CRP) (4.3±6.8 mg/dL), caliper body fat (35.7%±6.3%), and total body fat mass (35.6%±8.5%) were above normal limits. Nineteen/84 (23%) patients had CAS at baseline. Deterioration or stabilization/improvement of CAS was observed in 9/55 (16.4%) and 46/55 (83.6%) patients with follow-up data, respectively. Baseline body fat mass, visceral fat level, skeletal muscle mass, caliper body fat, BMI, ascites, Karnofsky index, RM, and CRP, as well as tumor response were not predictive of CAS deterioration. CONCLUSION: Nutritional decline and onset or deterioration of CAS are difficult to predict. Careful measuring and monitoring of nutritional parameters and CAS in all patients seems to be necessary in order to identify those patients in need of enteral/parenteral nutrition support.
