The effects of Ginger combined with Rhubarb on hyperuricemia in mice
10.3969/j.issn.1005-1678.2017.08.004
- VernacularTitle:生姜配伍大黄抗高尿酸血症实验研究
- Author:
Jiefang ZHOU
;
Haizhu FAN
- Keywords:
ginger;
rhubarb;
compatibility;
hyperuricemia
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):9-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was aimed to investigate the effects of Ginger combined with Rhubarb on hyperuricemia in mice. Methods The mice hyperuricemic model was made by orally administering yeast extract, The mice were randomly divided into 7 groups,includinglow,middle and high dose of Ginger combined with Rhubarb group, Rhubarb group, and allopurinol group was given corresponding drugs respectively by gavage, and the uric acid (uA), creatinine (Cr), urea nitrogen (BUN) level in blood and XOD activity in liver were observed for all mice in each group. Results Compared to hyperuricaemia model control group,UA level and XOD activity in liver of mice of the three doses of Ginger combined with Rhubarb groups received dose-dependent decrease. Conclusion Ginger combined with Rhubarb can reduce UA level and XOD activity in liver in hyperuricaemia mice model.
