Analysis of 4 cases of hepatic function failure caused by tigecycline

VernacularTitle:4例替加环素致肝功能衰竭的临床分析
Author: Jianbiao WU ; Chunhong ZHANG
Keywords: tigecycline; hepatic function failure; adverse drug reaction
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(8):372-373
CountryChina
Language:Chinese
Abstract: Objective To pay more attention to the adverse drug reactions caused by tigecycline. Methods Four cases in our hospital which happened acute or subacute liver failure after the uses of tigecycline were analyzed, including age, basic disease, drug combination,the time when liver function failure happen ,dosage of tigecycline and the course of treatment. Results The aged of four patients was 49-77 years old, the average age (67.5±12.79)years; the time when liver failure happened from 6 d to 20 d, the average(11.75±6.24) d; the course of treatment was 9 d to 23 d, the average(9.75±6.63) d; the total dose of tigecycline was 900 mg to 3650 mg, the average (1812.5±1243.23) mg.The four patients have many basic diseases, combined with many drugs, all of them have mechanical ventilation. Conclusion More attention should be paid to adverse events caused by tigecycline.