Epidemiological study of antibody to pertussis toxin IgG in newborns in Shunyi District of Beijing in 2016
10.3760/cma.j.issn.1007-9408.2017.08.009
- VernacularTitle:新生儿脐带血百日咳毒素IgG抗体水平的流行病学调查
- Author:
Yingjie SHEN
;
Fan YANG
;
Huizhen YI
;
Tianjiao ZHAO
;
Feitian LI
;
Hui ZHAO
;
Lihong HAN
;
Xiaoming XIN
;
Yajuan WANG
- Keywords:
Pertussis toxin;
Immunoglobulin G;
Whooping cough;
Fetal blood;
Epidemiologic studies;
Infant,newborn
- From:
Chinese Journal of Perinatal Medicine
2017;20(8):589-593
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of antibody to pertussis toxin (PT) IgG in newborns in Shunyi Women and Children's Hospital of Beijing Children's Hospital in 2016.Methods A total of 419 newborns were enrolled in this study.Umbilical cord blood sample was collected from each subject and detected by enzyme-linked immunosorbent assay to measure the concentration of PT-IgG.Besides,all newborns were followed up to January 31,2017.Chi-square test was used for statistical analysis.Results The detectable rate of umbilical cord blood samples for PT-IgG accounted for 30.1％ (126/419).The median antibody level was ＜ 5 U/ml,and the 90th and the 95th percentile were 14.3 and 24.0 U/ml,respectively.No cases of pertussis occurred at the end of follow-up.Conclusions The newborns born in Shunyi Women and Children's Hospital of Beijing Children's Hospital are generally lack of protective PT antibody.
