Clinical Study of Modified Liuwei Dihuang Decoction Combined with Metformin Plus Atorvastatin for Treatment of Type 2 Diabetes Mellitus Complicated with Hyperlipidemia
10.13359/j.cnki.gzxbtcm.2017.05.003
- VernacularTitle:六味地黄汤加减配合二甲双胍及阿托伐他汀治疗2型糖尿病合并高脂血症的临床研究
- Author:
Chuyan HUANG
;
Hongyu LIANG
- Keywords:
type 2 diabetes mellitus;
hyperlipidemia;
Liuwei Dihuang Decoction;
metformin;
atorvastatin
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(5):635-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of modified Liuwei Dihuang Decoction (LDD) combined with metformin plus atorvastatin for the treatment of type 2 diabetes mellitus (T2DM) complicated with hyperlipidemia. Methods A total of 120 cases of T2DM patients complicated with hyperlipidemia were randomly divided into study group (N=60) and control group (N=60), which were treated with LDD combined with metformin plus atorvastatin orally, and with oral use of metformin plus atorvastatin respectively. The course of treatment lasted for 12 weeks. Before and after treatment, we compared the blood levels of fasting blood glucose (FBG), 2-hour postprandial blood glucose(2hPG), glycosylated hemoglobin(HbA1C), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), and low-density lipoprotein cholesterol(LDL-C) in the two groups. After treatment, we evaluated the therapeutic effect of the two groups. Results (1) The total effective rate of the study group was 95.0％, and that of the control group was 83.3％, the effective rate of the study group being significantly higher than that of the control group (P < 0.05). (2) After treatment, the blood levels of FBG, 2hPG and HbA1C of both groups were significantly lower than pre-treatment levels (P <0.001), and the levels of FBG, 2hPG and HbA1C of the study group were significantly lower than those of the control group (P<0.05, P<0.01 or P<0.001). (3) After treatment, the TC, TG and LDL-C levels of both groups were significantly lower and HDL-C was higher than pre-treatment levels (P < 0.001); the levels of TC and TG levels of the study group were significantly lower and HDL-C was higher than those of the control group (P < 0.05 or P < 0.001). Conclusion LDD combined with metformin plus atorvastatin exerts certain effect for the treatment of T2DM complicated with hyperlipidemia, and is more effective than metformin or atorvastatin alone.
