Studies on Anti-inflammatory and Analgesic Effects of Baihuadan Analgesic Spray
10.13359/j.cnki.gzxbtcm.2017.05.022
- VernacularTitle:白花丹止痛喷雾剂的抗炎镇痛作用研究
- Author:
Limin CAI
;
Zhichao TAN
;
Shengchao YUAN
;
Guanglong ZENG
- Keywords:
Baihuadan Analgesic Spray/pharmacology;
anti-inflammation;
analgesia;
disease models,animal;
mice;
rats
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2017;34(5):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-inflammatory and analgesic effects of Baihuadan Analgesic Spray, so as to provide theoretical basis for further development of new drugs. Methods Prostaglandin E2 (PGE2) in the inflammatory tissues of mice with xylene-induced auricular inflammation and in the rats with albumen-induced pedal swelling were measured for the observation of anti-inflammation action of Baihuadan Analgesic Spray. The pain threshold in mouse hot-plate test and mouse acetic acid writhing test was determined to observe the analgesic effect of Baihuadan Analgesic Spray. Results Middle dose of Baihuadan Analgesic Spray (1 mg/mL) significantly reduced the auricular swelling rate induced by xylene in mice, improved the pain threshold of mice and prolonged pain latency in hot plate test (P < 0.05 or P < 0.01). High dose of Baihuadan Analgesic Spray (2 mg/mL) reduced the content of PGE2 in pedal inflammatory tissues (P < 0.05), and the effect on reducing the times of mouse writhing was obviously superior to that of the Voltaren Gel group. Conclusion Baihuadan Analgesic Spray has obvious anti-inflammatory and analgesic effects.
