The Biochemical Markers of Coronary Heart Disease Correlates Better to Metabolic Syndrome Defined by WHO than by NCEP-ATP III or IDF in Korean Type 2 Diabetic Patients.
10.4093/kdj.2008.32.2.157
- Author:
Dong Mee LIM
1
;
Keun Young PARK
;
Gwan Pyo KOH
Author Information
1. Department of Endocrinology, College of Medicine, Konyang University, Korea.
- Publication Type:Original Article
- Keywords:
Cardiovascular disease;
Diabetes mellitus;
Metabolic syndrome
- MeSH:
Adenosine Triphosphate;
Biomarkers;
C-Reactive Protein;
Cardiovascular Diseases;
Coronary Disease;
Diabetes Mellitus;
Homocysteine;
Humans;
Risk Factors;
Uric Acid
- From:Korean Diabetes Journal
2008;32(2):157-164
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Metabolic syndrome (MetS) is constellation of cardiovascular risk factors. There are three typically used definitions of MetS proposed by WHO, IDF and NCEP-ATP III. We conducted this study to compare the associations of MetS by WHO, IDF and NCEP-ATP III definition to various metabolic markers of coronary heart diseases in Korean type 2 diabetes patients. METHODS: We enrolled 151 Korean type 2 diabetes patients in one hospital. Anthropometric and biochemical parameters, including high-sensitivity C-reactive protein (hsCRP), homocysteine, uric acid were measured. And then, we divided MetS group from non-MetS group according to three other definitions. RESULTS: Serum hsCRP level was higher in those with MetS group than non-MetS group by WHO definition (0.33 +/- 0.36 mg/dL vs 0.18 +/- 0.26 mg/dL, P < 0.001). But, there are no difference in MetS group and non-MetS group by IDF and NCEP-ATPIII definition. (By IDF, 0.28 +/- 0.31 mg/dL vs 0.25 +/- 0.34 mg/dL, P = 0.64; By NCEP-ATP III, 0.28 +/- 0.33 mg/dL vs 0.22 +/- 0.32 mg/dL, P = 0.41). Uric acid and homocysteine levels were higher in those with MetS by WHO definition (P < 0.05). Similarly, analyses according to IDF and NCEP ATP III definition showed no significant difference. CONCLUSION: In conclusion, WHO definition of MetS has a stronger relationship with the biochemical markers of coronary heart disease in Korean type 2 diabetes patients.
