Diagnostic Value of Detecting Plasma Vitamin B12 and Homocysteine Subacute Combined Degeneration of the Spinal Cord
10.3969/j.issn.1671-7414.2017.04.012
- VernacularTitle:血清维生素B12及同型半胱氨酸检测在脊髓亚急性联合变性中的诊断价值
- Author:
Xin ZHANG
;
Xiling LIU
;
Yue LIU
- Keywords:
subacute combined degeneration of the spinal cord;
vitamin B12;
homocysteine
- From:
Journal of Modern Laboratory Medicine
2017;32(4):43-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the diagnostic value of detecting plasma vitamin B12 and Homocysteine (Hcy) in subacute combined degeneration of the spinal cord (SCD).Methods Parents of SCD (n=29) and subjects (n=74) without spinal cord diseases were enrolled from the clinic of Shaanxi Provincial People's Hospital from April 2014 to July 2016.The plasma vitamin B12 and Hcy concentrations were detected using Chemiluminescence Immunoassay (CLIA) and enzyme-linked immuno sorbent assay (ELISA) respectively,and compared using chi-square between the SCD and control groups.Sensitivity rate,specific rate,and diagnose accordance rate were evaluated.Results The plasma homocysteine and vitamin B12 concentrations in SCD and control groups were 49.41 μmol/L vs 12.36 μmol/L,44.35 pg/ml vs 166.75 pg/ml,with significant differences (U=343.50,800.00,P＜0.05).Negative correlation existed between the concentrations of vitamin B12 and Hey (r=-0.248,P=0.012).The sensitivity rates of vitamin B12 and Hcy detections were 55.2％ vs 89.7％,which had significant differences (x2 =8.631,P=0.003),and the diagnose accordance rate (69.9％ vs 64.1％) of the former was higher (x2 =4.175,P=0.041).Conclusion The plasma Hcy and vitamin B12 concentration detections had definite diagnostic value in SCD,and Hcy had higher sensitive rate,which can improve the diagnostic rate of SCD in the early stage.
