Preparation and Characterization of Aspirin Phospholipid Complex
10.6039/j.issn.1001-0408.2017.25.28
- VernacularTitle:阿司匹林磷脂复合物的制备及其表征
- Author:
Zhiyong HE
;
Chaohua WU
;
Junli YAN
;
Haizhi LI
;
Xiangchun SHEN
;
Ling TAO
- Keywords:
Aspirin;
Phospholipid complex;
Preparation technology;
Spectroscopic properties
- From:
China Pharmacy
2017;28(25):3562-3565
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare aspirin phospholipid complex (ASP-PC) and conduct the characterization. METHODS:Using the combination rate of ASP and PC as index,single factor test was used to screen the preparation method of ASP-PC,PC type,solvent type,reaction time,reaction temperature,solvent volume and drug-lipid ratio. The verification test was conducted. UV spectrophotometry,Thermogravimetric analysis,X-ray diffraction and Fourier transform infrared spectroscopy were used for the characterization of ASP-PC. RESULTS:Magnetic stirring-condensing reflux method was adopted,drug-soybean phospholipids ratio was 1:3 (mol/mol),solvent was tetrahydrofuran,reacting for 3 h under 58 ℃. The average combination rate of prepared ASP-PC was 83.52％(RSD=1.16％,n=3). Compared with ASP,physical mixture of ASP and PC,UV spectrum showed that ASP-PC had no new absorption peak. Thermogravimetric analysis,X-ray diffraction and Fourier transform infrared spectroscopy showed the ASP and PC in ASP-PC were interacted;and ASP-PC changed little in quality within 0-300 ℃. CONCLUSIONS:ASP-PC can be successfully prepared,in which,ASP and PC were combined successfully;while there are still trace amounts of ASP in the form of crystals.
