Changes in Gene Expression Profile and Bioinformatics Analysis of Children with Severe Malaria
10.3969/j.issn.1671-7414.2017.04.010
- VernacularTitle:儿童恶性疟疾患者外周血基因表达谱的改变及生物信息学特征分析
- Author:
Wei YANG
;
Jing PENG
;
Qiuxian HE
;
Rongqiang ZHANG
- Keywords:
plasmodium;
malaria;
differentially expressed genes;
bioinformatics
- From:
Journal of Modern Laboratory Medicine
2017;32(4):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct bioinformatics analysis of children with severe malaria to find out the key gene changes in order to provide a new basis for the prevention and treatment of malignant malaria.Methods Microarray gene chip data was downloaded from public databases GEO and imported into the analysis software STRING,PANTHER and GenClip.The gene expression profiles,protein interaction networks,the process of molecular biology,gene function were analyzed.Results 623(1.93 ％) differentially expressed genes had a good diagnostic capabilities in the diagnosis of mild and severe malaria.OAS2,OAS3,IFIT3 and USP18 were the core sub-network node of the Protein-Protein Interactions.Differentially expressed genes mainly involved in the body's immune defense,immune response,response to external stimuli,the biological function of type 1 interferon activation pathways.Conclusion The progress of malaria of children may be in the regulation of OAS2,OAS3,IFIT3,USP18 and children's immune defense capacity decreased,the malaria began to progress more easily.
