Relationship between Serum MMP-9 ,Gal-3 ,TGF-β1 and Pulmonary Function in Children with Bronchial Asthma
10.3969/j.issn.1671-7414.2017.04.021
- VernacularTitle:支气管哮喘患儿血清MMP-9,Gal-3和TGF-β1与肺功能的关系研究
- Author:
Yanping FAN
;
Jiaqi YI
;
Min WU
- Keywords:
bronchial asthma;
matrix metalloproteinase-9;
serum galectin-3;
transforming growth factor-beta 1
- From:
Journal of Modern Laboratory Medicine
2017;32(4):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum MMP-9,Gal-3,TGF-β1 and lung function in children with bronchial asthma.Methods The serum levels of matrix metalloproteinase-9 (MMP-9),serum galectin-3 (MMP-9),serum metalloproteinase-3 (MMP 9) and serum albumin were measured in 218 pediatric children between March 1,2012 and August 31,2016 in Shenzhen Longhua New District People's Hospital pediatric outpatient clinic.FEV1％,FEV1/FVC and FEF50 were measured and compared respectively with the index data of the control group.The lung function of the children was significantly higher than that of the control group (P＜0.05).Mild group and severe group children above.Results Serum levels measured in 218 children (F=35.34,46.51,56.73,all P＜0.05).The data of any two groups also showed statistical difference after q test,and the difference was statistically significant (FEV1 ％),1-second forced expiratory volume/forced vital capacity percentage (FEV1/FVC),forced expiratory 50％ (FEF50) of the first-second forced expiratory volume/forced expiratory volume of 1 second (F=78.13,52.69,26.24,all P＜0.05).After the q test,the data of any two groups were analyzed by ANOVA.Between the data were also statistically significant differences.Conclusion MM-9,Gal-3 and TGFβ1 in bronchoalveolar lavage and the degree of pulmonary function decline have close ties.
