Research progress of matrix metalloproteinase-9 in kidney disease
10.3760/cma.j.issn.1008-1372.2017.08.049
- VernacularTitle:基质金属酶-9在肾脏病中的研究进展
- Author:
Xiangyang YU
;
Lili JIA
;
Wenli YU
;
Yiqi WENG
;
Hongyin DU
- Keywords:
Matrix metalloproteinase 9;
Kidney diseases;
Review
- From:
Journal of Chinese Physician
2017;19(8):1278-1280,封3
- CountryChina
- Language:Chinese
-
Abstract:
Kidney plays an important role in maintaining the homeostasis as an important excretory and endocrine organ.The occurrence and development of kidney disease is closely associated with glomerular filtration barrier dysfunction and renal interstitial remodeling.Matrix metalloproteinase-9 (MMP-9),a major enzyme in the extracellular matrix (ECM),plays an important role in the process of kidney disease by regulating the ECM components and its interaction with cytokines.The paper reviews the pathophysiology of MMP-9 in glomerular filtration barrier dysfunction and renal fibrosis to provide a theoretical basis for clinical treatment of kidney disease.
