The study of daily glucose change in insulin resistance with polycystic ovary syndrome women
10.3760/cma.j.issn.1008-1372.2017.08.006
- VernacularTitle:胰岛素抵抗的多囊卵巢综合征患者血糖波动变化研究
- Author:
En LIU
;
Ying ZHANG
;
Lin CHEN
;
Jiahe YAN
;
Xin LIU
;
Tingting MAI
- Keywords:
Insulin resistance;
Polycystic ovary syndrome/ME;
Blood glucose/ME
- From:
Journal of Chinese Physician
2017;19(8):1144-1147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical metabolic characteristics and the blood glucose variability in the insulin resistance polycystic ovary syndrome (PCOS) patients.Methods Totally 69 cases of PCOS patients were divided into two groups:PCOS with insulin resistance (PCOS-IR) group and PCOS without insulin-resistance (PCOS-NIR) group.Their clinical and metabolic characteristics were analyzed,and continuous glucose monitoring system (CGMS) was used to monitor the glucose concentration of subcutaneous interstitial fluid to reflect the blood glucose level.Mean blood glucose level (MBG) and its standard deviation (SDBG),mean amplitude of glycemic excursion (MAGE),peak level of postprandial plasma glucose as well as its peaking time during a 48-hour period CGMS were calculated.Results MBG,SDBG,large amplitude of glycemic excursions (LAGE),MAGE level in PCOS-IR group,were significantly higher than those in PCOS-NIR (P ＜ 0.05).Body mass index (BMI),triglycerides,glycated hemoglobin Alc (HbAlc),fasting blood glucose (FBG),2 hours glucose,free androgen index (FAI) level in PCOS-IR group were higher than in PCOS-NIR group (P ＜ 0.01).The difference of total cholesterol,low-density lipoprotein,mean of daily difference (MODD) level were not statistically significant (P ＞ 0.05).Conclusions PCOS-IR patients suffer from more serious metabolic disorder and blood glucose variability.
