Differentiating true progession from pseudoprogression in patients with gliobastomas using dynamic contrast-enhanced MRI
10.3760/cma.j.issn.1008-1372.2017.08.008
- VernacularTitle:动态对比增强MRI在鉴别胶质瘤真、假性进展中的应用
- Author:
Xibin XIA
;
Pingsheng HU
;
Zhengwen HE
;
Fengjiao YANG
;
Feng BI
;
Qiang LU
;
Xiaoping YU
- Keywords:
Magnetic resonance imaging;
Glioma/DI;
Diagnosis,differential
- From:
Journal of Chinese Physician
2017;19(8):1152-1155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application and manifestation of dynamic contrastenhanced MRI (DCE-MRI) in differentiating true progession from pseudoprogression in patients with gliobastomas.Methods Twenty five glioma patients were treated with postoperative concurrent chemoradiotherapy and enrolled in this study.All patients were underwent DCE-MRI using a 1.5T scanner.Fifteen patients were confimmed by secondary pathology or clinical and imaging follow-up of patients with gliomas true progession (TP),10 patients were pseudoprogress (PP).Nonparametric Mann-Whitney test was used to compare perfusion parameters between two groups (TP and PP),were used for receiver operating characteristic (ROC) curve analysis to clear if these parameters can be the indicators to differentiate true progession from pseudoprogression.Results Ktrans (volume transfer constant),Ve (fractional volume of extravascular extracellular) values between TP and PP glioma groups were statistically significant,K and Ve values were significantly higher in the TP group than in the PP group (P ＜ 0.05).The areas under the ROC curve are 0.990 and 0.847,respectively.Kep (efflux rate constant) value,Vp (fractional volume of plasma) value in the identification of glioma TP group and PP group was not statistically significant (P ＞ 0.05).Conclusions DCE-MRI can be used to identify glioma TP and PP,Ktrans value and Ve value have clinical significance.
