The research progress on the biological characteristics of PAK2 and its correlation with tumor
10.11958/20170251
- VernacularTitle:PAK2的生物学特性及其与肿瘤关系的研究进展
- Author:
Baoyu LI
;
Lijie HE
;
Xianglian ZHANG
;
Hui LIU
- Keywords:
antineoplastic agents;
molecular mechanisms of pharmacological action;
review;
p21 activating kinase 2
- From:
Tianjin Medical Journal
2017;45(9):1001-1004
- CountryChina
- Language:Chinese
-
Abstract:
The activation of p21 kinase 2 (PAK2) has a certain value in cancer research, since its participation in a series of intracellular biological activities. There is a relatively little research on its relationship with the development of tumors. PAK2 can be activated by a variety of upstream signals, especially small G protein Rho family of Rac and Cdc42, and it participates in a variety of important signaling pathways and cell function regulation. Abnormal expression of PAK 2 has been reported in various tumors, which involves in cytoskeletal remodeling, cell motility, apoptosis, signal transduction, gene transcription, translation and angiogenesis. Therefore, PAK2 plays an important role in tumor occurrence and development. The study on PAK2 and the targeting therapy for anti-PAK2 provides a new sight on the treatment and prevention of tumor.
