Changes and clinical significance of CD4 + CD25 + Foxp3 + regulatory T cell and relative cell factors in peripheral blood of steroid-resistant allergic rhinitis patients
10.3760/cma.j.issn.1008-1372.2017.08.013
- VernacularTitle:CD4+CD25+Foxp3+调节性T细胞及相关细胞因子在类固醇抵抗型变应性鼻炎患者外周血中的变化及意义
- Author:
Gang REN
;
Jue XU
;
Xudong LUO
;
Longjiang LAN
;
Manqun LI
;
Bingliang MA
;
Jianqiu WANG
- Keywords:
Rhinitis,allergic,perennial;
CD4-positive T-lymphocytes;
T-lymphocytes,regulatory;
Interleukin-10/ME;
Transforming growth factor beta/ME
- From:
Journal of Chinese Physician
2017;19(8):1172-1175,1179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of CD4 + CD25 + Foxp3 + regulatory T cell (Treg) and relative cell factors in peripheral blood of steroid-resistant allergic rhinitis (AR) patients,and to study their functions in occurrence of steroid-resistant AR.Methods The CD4 + CD25 + Foxp3 + Treg cell in 30 cases general physical examination (The control group),30 cases steroid-sensitive AR patients (steroidsensitive group) and 30 cases steroid-resistant AR patients (steroid-resistant group) were detected by flow cytometry.The levels of serum interleukin 10 (IL-10) and transforming growth factor β1 (TGF-β1) in the three groups were detected by enzyme-linked immunoadsorbent assay (ELISA).Results Compare to the control group,proportion of CD4 + CD25 + Foxp3 + Treg cell and the levels of serum IL-10,TGF-β1 in steroid-sensitive group and steroid-resistant group were significantly reduced (P ＜ 0.01).The proportion of CD4 + CD25 + Foxp3 + Treg cell and the levels of serum IL-10,TGF-β1 in steroid-resistant group were decreased significantly than steroid-sensitive group (P ＜ 0.01).The proportion of CD4 + CD25 + Foxp3 + Treg cell were positively correlated with the serum IL-10,and TGF-β1 (P ＜ 0.01).Conclusions The reduced proportion of CD4 + CD25 + Foxp3 + Treg cell and lower serum IL-10,TGF-β1 play an important role in the occurrence of steroid-resistant AR patients.
