Childhood fibrillary glomerulonephritis:one case report and literature review

VernacularTitle:儿童纤维性肾小球肾炎1例报告并文献复习
Author: Hongwen ZHANG ; Jieyuan CUI ; Baige SU ; Yong YAO
Keywords: fibrillary glomerulonephritis; renal biopsy; child
From: Journal of Clinical Pediatrics 2017;35(9):687-690
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical features, diagnosis, and treatment of childhood fibrillary glomerulonephritis (FGN). Methods The clinical data of a child with FGN in April 2016 were analyzed retrospectively. Results A 12-year-old boy, who presented significant proteinuria (mainly albumin), hypoalbuminemia, hypercholesterolemia, and persistent microscopic hematuria in May 2010, met the criteria of nephrotic syndrome. Renal biopsy in May 2010 showed mesangial proliferative glomerulonephritis combined with glomerulosclerosis. It was not effective by treatment with intravenous infusion of methylprednisolone and prednisolone, and there were no responses by the combination with mycophenolate mofetil and traditional Chinese medicine. After admission, the second renal biopsy was performed. Under the light microscope, the moderate mesangial proliferative glomerulonephritis combined with membranoproliferative changes was observed. Under the electron microscope, the FGN was confirmed. Conclusion The first case of childhood FNG was diagnosed in China.