Association of KL gene G-395A polymorphisms with coronary heart disease and serum cystatin C level in the elderly Chinese Han population in central China
10.3969/j.issn.1671-8348.2017.23.012
- VernacularTitle:老年汉族人群KL基因G-395A多态性与冠状动脉粥样硬化性心脏病及胱抑素C水平的相关性分析
- Author:
Wei LIU
;
Shaoying ZHANG
;
Huimin XU
;
Sisi GUAN
- Keywords:
Klotho gene;
polymorphism,single nucleotide;
cysteine proteinase inhibitors;
Atherosclerosis;
aged
- From:
Chongqing Medicine
2017;46(23):3206-3208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the single nucleotide polymorphism at G-395A site of the Klotho (KL) gene and to analyze its correlation with the coronary heart disease(CHD) and serum Cystatin C(Cys C) level in the elderly Chinese Han population in central China.Methods A case-control study was conducted in 278 elderly Chinese Han population in this department,who were divided into CHD group(138 cases)and control group(140 cases) according to bear angiography coronary or not.G-395A polymorphism of KL gene was determined by TaqMan Gene probe method,and the relationship between G-395A polymorphism and coronary heart disease and serum Cys-C level was analyzed.Results Compared with the control group,the frequency of GG genotype of G-395A in CHD group was significantly higher,and the frequency of AA genotype and AG genotype was not statistically significant.The levels of Cys-C in the GG genotype were higher than those in the AA and AG genotypes both in the control group and coronary heart disease group.Conclusion In the elderly Han population in central China,the risk of suffering coronary heart disease is higher among the GG genotype of the G-395A locus of the KL gene.KL gene G-395A site gene mutation may affect the development of atherosclerosis by affecting blood Cys-C levels.
