Resting state functional MRI evaluation of constraint abstinence duration for regional homogeneity in heroin addicts
10.13929/j.1003-3289.201612103
- VernacularTitle:强制戒断时间对海洛因成瘾者大脑局部一致性影响的静息态功能MRI
- Author:
Xin LI
;
Qiang LI
;
Jiajie CHEN
;
Yongbin LI
;
Hong SHI
;
Jiuhua XUE
;
Wei LIU
;
Wei LI
;
Wei WANG
- Keywords:
Heroin;
Regional homogeneity;
Abstinence;
Functional magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2017;33(8):1171-1175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of constraint abstinence duration on regional homogeneity (ReHo) of heroin addicts in resting state.Methods Twenty heroin addicts abstinent for 6 months (PA6 group),sixteen heroin addicts abstinent for 11 months (PA11 group) and 30 demographically matched healthy controls (HC group) were enrolled.ReHo values were calculated and difference among three groups was analyzed.The relationship between ReHo values of differential brain regions and abstinent duration was performed with Pearson method.Results The results demonstrated statistically significant difference in ReHo values among three groups in the left parahippocampal gyrus,caudate,insula,cingulate gyrus,postcentral gyrus and right orbitofrontal cortex.Compared with the PA6 group,the PA11 group demonstrated lower ReHo value in left parahippocampal gyrus,caudate,insula,cingulate gyrus and postcentral gyrus,ReHos value were higher than PA6 and HC in right orbitofrontal cortex.Meanwhile,the ReHo values of left parahippocampal gyrus (r=0.53,P=0.000 8),caudate (r=0.54,P=0.000 6),insula (r=0.62,P＜0.000 1),cingulate gyrus (r=0.47,P=0.003 5) and postcentral gyrus (r=0.35,P 0.034 8) were negatively correlated with abstinence duration and ReHo value of right orbitofrontal cortex (r=0.66,P＜0.000 1) were positively correlated with abstinence duration.Conclusion During long-term abstinence,most of heroin addicts' damaged brain regions (mainly involved in craving,inhibitory control,learning and memory) tends to be normal,thus benefit reducing the risk of relapse,but motivation related brain region's (orbitofrontal cortex) neural activity increases abnormally,that may be one of the important reasons for relapse after abstinence.
