Diffusion tensor imaging tractography in assessing damage of limbic system pathways of relapsing-remitting multiple sclerosis patients
10.13929/j.1003-3289.201612001
- VernacularTitle:纤维束示踪成像评价复发缓解型多发性硬化患者边缘系统纤维通路损伤
- Author:
Qi LUO
;
Yongmei LI
;
Yongliang HAN
;
Dan LIAO
;
Chun ZENG
;
Jingjie WANG
;
Silin DU
- Keywords:
Diffusion magnetic resonance imaging;
Tractography;
Limbic system;
Multiple sclerosis
- From:
Chinese Journal of Medical Imaging Technology
2017;33(8):1176-1180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the damage of limbic system pathways in relapsing-remitting multiple sclerosis (RRMS) by diffusion tensor imaging (DTI) tractography.Methods DTI tractography was used to acquire fiber numbers,fractional anisotropy (FA),mean diffusivity (MD) of cingulum,fornix,and uncinate fasciculus (UF) in 20 RRMS patients (MS group) and 20 healthy volunteers (control group),and statistical analysis was performed.Results Compared with control group,lower FA value (P＜0.01) and higher MD value (P＜0.05) were found in cingulum,fornix and UF of MS group,and the fiber numbers of fornix decreased in MS group (P＜0.001).There were significant differences between the left and the right UF in fiber numbers and FA value of control group and the fiber numbers of MS group.Negative correlations were found between FA value of cingulum and UF and EDSS scores in MS group (r=-0.572,-0.665,both P＜0.05),and positive correlations were found between MD value and EDSS scores (r=0.627,0.603,both P＜0.05).Conclusion DTI tractography is valuable in assessing MS associated limbic system damage and in monitoring the clinical progression of the disease.
