Clinical value of contrast-enhanced ultrasonography and serum markers in assessing portal hypertension in patients with decompensated liver cirrhosis
10.3969/j.issn.1672-8467.2017.04.012
- VernacularTitle:超声造影联合血清学指标评估失代偿期肝硬化患者门静脉高压的临床价值
- Author:
Qing ZHANG
;
Ling LI
;
Hong DING
;
Shiyao CHEN
- Keywords:
liver cirrhosis;
portal hypertension;
hepatic venous pressure gradient;
contrast-enhanced ultrasonography;
non-invasion
- From:
Fudan University Journal of Medical Sciences
2017;44(4):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the possibility of assessing portal hypertension in patients with decompensated liver cirrhosis via contrast-enhanced ultrasonography and common serum markers.Methods Fifty-four patients with decompensated liver cirrhosis were divided into two groups according to hepatic venous pressure gradient (HVPG):HVPG＜12 mmHg (1 mmHg=0.133 kPa) and HVPG ≥12 mmHg.The non-invasive index of routine blood test,liver function,coagulation function,Child-pugh score (CPS) and the results of contrast-enhanced ultrasound such as hepatic artery arrival time (HAAT),hepatic vein arrival time (HVAT)、portal vein arrival time (PVAT),hepatic artery to henatic vein arrive transmit time (HA-HVTT) and portal vein to hepatic vein arrive transmit time (PV-HVTT) were assessed by univariate analysis and multivariate Logistic regression analysis,and then were used to generate a diagnostic model.The receiver operating characteristic curve was also used for analysis.Results The non-invasive model is Y =-0.217 × PV-HVTT + 1.526 × CPS-7.097.When the area under ROC curve (AUROC) was ≥0.857 and the best cutoff value was ≥0.631,and the sensitivity and specificity in judging HVPG≥ 12 mmHg were 87.5 ％ and 78.6％,respectively.Conclusions The model composed of PV-HVTT and CPS could be used to assess portal hypertension.
