The pathgenetic role and potential clinical application of miRNAs in patients with Behcet's disease
10.3969/j.issn.1672-8467.2017.04.026
- VernacularTitle:微小核糖核酸在白塞病发病中的作用及其临床应用前景
- Author:
Jingfen YE
- Keywords:
miRNA;
inflammatory cytokines;
Behcet's disease
- From:
Fudan University Journal of Medical Sciences
2017;44(4):538-541,547
- CountryChina
- Language:Chinese
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Abstract:
As the endogenous mediators of RNA interference,miRNA play biological roles by inducing post-transcriptional silence of gene expression.Previous studies showed that miRNAs have multiple regulating potential to immune cells,involved in regulation of innate and adaptive immunity.Recently,aberrant expression of miRNAs have been confirmed to be relevant to the pathogenesis of Behcet's disease (BD) by regulating the expression of inflammatory cytokines in immune cells,which may become of its diagnostic marker and therapeutic target in the future.In this review,we discuss how miRNAs regulate autoimmunity.Several miRNAs associate with the pathogenesis of BD,thus they have the potential clinical application value.
