Effects of levothyroxine intervention on premature delivery occurrence risk in early pregnant women complicating subclinical hypothyroidism:a meta analysis
10.3969/j.issn.1673-4130.2017.16.009
- VernacularTitle:L-T4干预对妊娠早期合并亚临床甲状腺功能减退症孕妇发生早产风险的荟萃分析
- Author:
Fang LIU
;
Xiaomei MI
;
Xiaoqiong YANG
;
Huilei MA
;
Xiuzhen LIANG
- Keywords:
pregnancy;
subclinical hypothyroidism;
preterm labor;
meta-analysis;
levothyroxine
- From:
International Journal of Laboratory Medicine
2017;38(16):2199-2201,2204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of levothyroxine(L-T4) intervention on premature delivery occurrence risk in early pregant women complicating subclinical hypothyroidism.Methods The databases of PubMed,EMBASE,EBSCO,Cochrane library,CBM and Wanfangdata were retrieved for collecting the related literatures on pregnancy complicating subclinical hypothyroidism published from January 1980 to March 2017.The undesirable studies were deleted according to the inclusion standard.The meta analysis was performed by using the RevMan5.3 software.Results (1) The 12 articles on premature delivery occurrence risk in pregnan women complicating subclinical hypothyroidism without intervention were included(accumulated 5 612 cases of samples and accumulated 368 cases of premature delivery),802 pregnant women received L-T4 intervention,the control group (4 810 cases) was the pregnant women of normal thyroid.The merged OR was 3.46,95%CI 2.64-4.54,P<0.05.(2) Twenty-one articles on premature delivery occurrence risk in pregnan women complicating subclinical hypothyroidism treated by L-T4 in meta analysis were included(accumulated 2561 cases of samples and accumulated 286 cases of premature delivery).The merged ORwas 5.37,95%CI 3.90-7.38,P<0.05).Conclusion Early pregnancy complicating subclinical hypothyroidism can increase the risk of preterm birth,whereas adopting the L-T4 intervention therapy can significantly reduce the risk of premature delivery occurrence.
