Expressions of Bile Acid Receptor FXR and TGR5 in Patients with Ulcerative Colitis
10.3969/j.issn.1008-7125.2017.08.005
- VernacularTitle:胆汁酸受体FXR和TGR5在溃疡性结肠炎中的表达
- Author:
Min WEI
;
Wenfang CHENG
;
Jing PING
;
Lu XIA
- Keywords:
TGR5;
FXR;
Colitis;
Ulcerative;
Immunohistochemistry
- From:Chinese Journal of Gastroenterology
2017;22(8):465-468
- CountryChina
- Language:Chinese
-
Abstract:
Background:The incidence of ulcerative colitis (UC)in developed countries is higher than that in developing countries,which may be related with westernized lifestyle,especially high animal protein and low complex carbohydrate diet. With the increased high fat and meat intake,synthesis and secretion of bile acid in liver is also increased,which may have an impact on the occurrence of UC. Aims:To investigate the expressions of farnesoid X receptor (FXR)and G protein-coupled bile acid receptor 5 (TGR5)in patients with UC. Methods:Thirty patients with active UC from January 2013 to June 2016 at the Affiliated Jiangning Hospital of Nanjing Medical University were enrolled,and 30 healthy subjects were served as controls. Expressions of FXR and TGR5 were determined by immunohistochemistry. Results:Compared with control group,expression of FXR was significantly decreased in UC patients (4. 63 ± 2. 07 vs. 6. 91 ± 2. 62,P =0. 00),however,no significant difference in expression of TGR5 was found between the two groups (6. 70 ± 2. 90 vs. 6. 11 ± 2. 44,P = 0. 40). Expression of FXR was significantly increased in right hemicolon colitis than in left hemicolon colitis (P < 0. 05). Conclusions:There is a significant decrease in FXR in active UC patients,indicating that FXR may have some role in the pathogenesis of UC,however,TGR5 may have no obvious effect in the pathogenesis of UC.
