Role of MiR-20a and its Diagnostic Value in Gastric Cancer
10.3969/j.issn.1008-7125.2017.08.015
- VernacularTitle:MiR-20a在胃癌中的作用及其诊断价值探讨
- Author:
Mengjuan LIN
;
Baoping YU
- Keywords:
MicroRNAs;
MiR-20a;
Stomach Neoplasms;
Diagnosis
- From:
Chinese Journal of Gastroenterology
2017;22(8):506-509
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the most common malignancies worldwide. Early diagnosis and intervention is the key to improve the prognosis of patients with gastric cancer. Expression of miR-20a is up-regulated in the circulating blood of gastric cancer patients,cancer tissues and cell lines,and has been demonstrated to be closely related to the clinicopathological characteristics and prognosis of gastric cancer. MiR-20a promotes the proliferation of gastric cancer cells,regulates the self-renewal of gastric cancer stem cells,and induces chemoresistance via a variety of mechanisms. Detection of serum/ plasma miR-20a alone or in combination with other miRNAs is helpful for the early diagnosis and prediction of progression,relapse and prognosis of gastric cancer. MiR-20a has the potential to be used as a novel and noninvasive biomarker for gastric cancer.
