A modified rabbit model of gouty knee arthritis
10.3969/j.issn.2095-4344.2017.24.019
- VernacularTitle:一种改良膝关节痛风性关节炎兔模型
- Author:
Qi LI
;
Xuxu CHEN
;
Jian LI
- From:
Chinese Journal of Tissue Engineering Research
2017;21(24):3881-3887
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:An ideal animal model is important for studying gouty arthritis. However, a lack of perfect animal model of gouty arthritis delays the progress in searching for a novel drug and treatment method. OBJECTIVE:To evaluate the effectiveness of the modified rabbit model of gouty knee arthritis. METHODS:New Zealand white rabbits were selected and randomly divided into four groups. Except bIank control group received no intervention;the rabbit greater omentum was removed, which was wrapped with nothing (sham operation group), impIanted with 0.1 g/L monosodium urate crystal suspension (conventionaI group), or 100 mg/kg monosodium urate crystal (modified group) into the suprapatellar cyst of the rabbit right knee. The swelling degree, motor function, and inflammatory response of the knee joint were observed at 1, 2 and 3 days, 1, 2, 3, and 4 weeks after modeling to evaluate the advantages and disadvantages of the modified model. RESULTS AND CONCLUSION:The movement function in the modified group was significantly decreased within