Study progress of antiviral therapy in children with chronic hepatitis B
10.3760/cma.j.issn.2095-428X.2017.10.002
- VernacularTitle:慢性乙型肝炎患儿抗病毒治疗进展
- Author:
Hongfei ZHANG
;
Shishu ZHU
- Keywords:
Chronic hepatitis B;
Interferon;
Nucleos (t) ide analogues;
Treatment;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(10):724-726
- CountryChina
- Language:Chinese
-
Abstract:
The antiviral treatment for children with chronic hepatitis B virus(HBV) infection should be started in the immune active phase.Interferon (IFN) is the drug of first choice in most cases,however,the individual treatment and management of adverse effects need to be considered.Currently,Nucleos (t)ide analogues (NAs) can be used as the first choice only for those special children who can't use IFN.Efficacy will be seriously affected once the emergence of viral resistance mutants to NAs.However,there is high risk of relapse after the NAs are discontinued.Compared with the mono therapy,the therapeutic strategy of interferon combined with NAs have obtained better effect and safety in children with chronic HBV infection.
