Clinical significance of serum interleukin-1β and interleukin-6 levels in childhood hyperuricemia
10.3969/j.issn.1000-3606.2017.08.008
- VernacularTitle:儿童高尿酸血症血清IL-1β、IL-6水平及其临床意义
- Author:
Yuanling CHEN
;
Jiapei WANG
;
Nan SUN
;
Xiahua DAI
;
Yazhen DI
;
Mengjiao SHEN
;
Qianqian YING
- Keywords:
hyperuricemia;
interleukin-1β;
interleukin-6;
child
- From:
Journal of Clinical Pediatrics
2017;35(8):592-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of interleukin (IL)-1β and IL-6 in serum of children with hyperuricemia (HUA). Methods 142 children including 71 children with HUA (HUA group) and 71 control children (control group), healthy and inguinal hernia children were selected as control group. 71 HUA children were subdivided into GA (gout attacks) group (n=28) and NGA (non-gout attacks) group (n=43) according to whether they had a history of acute gout attacks, including sudden monoarthritis of rapid onset with intense pain and swelling or without. Enzyme-linked immunosorbent assay was used to measure the level of IL-1β and IL-6 in serum. Results Serum IL-1β and IL-6 levels of HUA children were significantly higher than those of control group (all P<0.05). Serum IL-1β and IL-6 levels of HUA children in GA group were significantly higher than those of NGA group (P<0.05). Serum IL-1β and IL-6 levels of GA group in acute phase was significantly higher than those of HUA children in remission stage、NGA group and control group (P<0.05). Serum IL-1β and IL-6 levels of GA group in remission stage and NGA group was significantly higher than those of control group (P<0.05). There were no significant differences between HUA children in remission stage and NGA group (P>0.05). The serum IL-1β and IL-6 levels of HUA children were positively correlated with WBC, neutrophils, monocytes, uric acid, ESR, CRP, BUN and Cr (all P<0.05), while not correlated with triglyceride, total cholesterol, LDL-C and HDL-C(all P<0.05). Conclusion IL-1β and IL-6 play an important role in the pathogenesis of HUA in children.
