Effect of mammalian target of rapamycin inhibitor on growth in children

VernacularTitle:哺乳动物雷帕霉素靶蛋白抑制剂对儿童体格生长的影响
Author: Jian CHEN ; Liping ZOU
Keywords: Mammalian target of rapamycin inhibitor; Growth; Child
From: Chinese Journal of Applied Clinical Pediatrics 2017;32(9):711-714
CountryChina
Language:Chinese
Abstract: The mammalian target of rapamycin (mTOR) disorders have a close relationship with autoimmune disease,tuberous sclerosis (TfSC),cancer,obesity and senescence.mTOR inhibitors are wildly used in pediatric renal transplantation and TSC.Growth is an important indicator of children health and safety evaluation of pediatric drugs must include impact on growth.No evidence showed mTOR inhibitors had side effect on growth in children.