Effects of cisplatin-alginate conjugate liposomes in cervical cancer-bearing nude mice

VernacularTitle:载顺铂纳米脂质体对荷宫颈癌HeLa细胞移植瘤裸鼠的体内作用
Author: Hua GAO ; Yunfei WANG ; Wenjing WANG ; Meiying ZHANG ; Qing LI ; Ying DING ; Wen DI
Keywords: nanoparticles; cervical cancer; tumor growth
From: Journal of Shanghai Jiaotong University(Medical Science) 2017;37(5):606-610
CountryChina
Language:Chinese
Abstract: Objective · To establish human cervical cancer xenografts in nude mice and investigate the antitumor therapeutic effects and safety of EGF modified cisplatin-alginate conjugate liposomes. Methods · Cervical cancer-bearing mouse model was established by subcutaneously injecting Hela cells in nude mice. Generalstate and xenograft growth of the mice were observed. Tumor volumes, tumor weights, and the body weights of mice during the treatment were recorded and analyzed. The expression levels of EGFR in xenografts were detected by immunohistochemistry. Results · ① EGFR was highly expressed in the xenografts. ② CS-EGF-Lip inhibited the tumor growth effectively (P=0.000). ③ The inhibition rates of tumor volume and tumor weight of CS-EGF-Lip were 80.22% and 58.60% respectively, which were betterthan those of cisplatin (P=0.000). ④ CS-EGF-Lip had minimal influence on body weight in mice (P=0.000). Conclusion · CS-EGF-Lip has more effective antitumoreffects than cisplatin in cervical cancer-bearing mice, which can inhibit tumor growth of solid tumors with enhanced efficacy and safety.