Role of myosin regulatory light chain phosphorylation in the pathogenesis of chronic heart failure
10.3969/j.issn.1674-8115.2017.08.023
- VernacularTitle:肌球蛋白调节性轻链磷酸化在慢性心力衰竭发生机制中的作用
- Author:
Shan HU
;
Gang WU
- Keywords:
myosin regulatory light chain;
chronic heart failure;
phosphorylation;
myocardial contractility
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(8):1165-1168
- CountryChina
- Language:Chinese
-
Abstract:
In the embryonic period, myosin regulatory light chain (MYL2) plays a pivotal role in the development and function of the heart. A large number of studies have previously confirmed that the mutation of MYL2 gene, also known as MLC2, confers intimate associations with hypertrophic cardiomyopathy. MYL2 gene mutation impacts the structure and function of myosin, thereby leading to the occurrence and progression of hypertrophic and dilated cardiomyopathy as well as the following chronic heart failure. Importantly, MYL2 phosphorylation renders crucial effects in the processes of cardiac contraction, ventricular torsion and cardiac function.
