Progress in the study of liver ischemia reperfusion injury
10.3760/cma.j.issn.1673-4203.2017.04.018
- VernacularTitle:肝脏缺血再灌注损伤的研究进展
- Author:
Yao LI
;
Bao ZHANG
;
Yong MA
- Keywords:
Liver;
Ischemia reperfusion;
Injury
- From:
International Journal of Surgery
2017;44(4):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Liver ischemia reperfusion injury is a common pathophysiological process in hepatic surgery,which is the consequence of multiple mechanisms such as oxidative stress,inflammatory reaction,apoptosis,and autophagy and so on.However,the molecular mechanisms behind these processes have not been completely elucidated,the current treatment of liver I/R injury is merely supportive care,and thus new therapeutic strategies are needed.The recent studies indicate that the ischemic precondition and pharmacological precondition may protect the liver against hepatic ischemiareperfusion injury.It will be an important clinical significance of further studying its molecular mechanisms and protective strategies.
