Adenosine to inosine acting on RNA enzymes 1 (ADAR1) contribute to the progression of tumor
10.3760/cma.j.issn.1673-4203.2017.04.019
- VernacularTitle:A-to-I RNA编辑酶1参与调控肿瘤的发生和发展
- Author:
Junjie LI
;
Zhuochao ZHANG
;
Wei ZHAO
;
Wen YIN
- Keywords:
ADAR1;
Tumor;
RNA editing;
A-to-I transition
- From:
International Journal of Surgery
2017;44(4):281-284
- CountryChina
- Language:Chinese
-
Abstract:
Tumor occurrence and development is a complicated process.Previous studies confirm that DNA mutations result in activation of downstream pathways of tumor cells.Recently,studies of post-translational modifications showed that RNA editing play an important role in transcriptional mechanism.Thus,RNA editing further enrich the diversity of RNA and protein,participate in the process of many diseases,including cancer.Recently,many studies have focused on the RNA editing enzymne ADAR1 because of the complexity role in tumorigenesis and progression.This article mainly reviewed the role of ADAR1 in the occurrence and development of tumors.
