Ameliorative effect of metformin on insulin resistance induced by olanzapine gavage in rats
10.3969/j.issn.1674-8115.2017.08.003
- VernacularTitle:二甲双胍对奥氮平灌胃大鼠胰岛素抵抗的改善作用
- Author:
Jiali SHI
;
Lei ZHANG
;
Ying QIAO
;
Yifeng SHEN
;
Huafang LI
- Keywords:
olanzapine;
metformin;
insulin resistance;
glucose tolerance
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(8):1064-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective · To investigate the effect of metformin on insulin resistance (IR)-related metabolic parameters in olanzapine-bearing rats.Methods · Thirty female SD rats were randomly divided into metformin intervention group, olanzapine group and control group. During the first 6 weeks,5 mg /(kg·d) olanzapine was given to the two test groups . The control group was given the same amount of saline. From the 7th week, the intervention group began to combine with metformin 500 mg / (kg·d), while the olanzapine group combined with the same amount of saline, continuing for 4 weeks.At the end of 6th week and 10th week, intraperitoneal glucose tolerance and homeostasis model assessment IR index were assessed. Results · The area under the glucose tolerance curve (P=0.040) and the IR index (P=0.000) were significantly higher for the intervention group and the olanzapine group than the control group at the end of 6th week. At the 10th weekend, the glucose tolerance (P=0.015) and IR index in the intervention group were significantly lower than those in the olanzapine group (P=0.001). Conclusion · Metformin may rectify the impaired glucose tolerance and improve IR induced by olanzapine partly.
