The role of hamartin in ischemia/hypoxia tolerance
10.3969.j.issn.1671-7856.2017.08.017
- VernacularTitle:Hamartin在低氧/缺血耐受中的作用
- Author:
Lin HOU
;
Shengdi XU
;
Zhuxia ZHANG
;
Guo SHAO
;
Lihua HUANG
- Keywords:
Hamartin;
Hypoxia/Ischemia;
Methylation
- From:
Chinese Journal of Comparative Medicine
2017;27(8):85-88
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia/ischemia is a common clinical pathophysiological process and cause of death,and it is a common problem in extreme conditions such as high altitude,astronautics and diving.Hamartin is a kind of effective endogenous neuroprotectant and could increase cell tolerance to acute hypoxia or ischemia, thus,is of significance to research.The role of hamartin in hypoxia/ischemia has been a research focus of many scientists.Elucidating the related protective effect and its DNA methylation on hypoxia/ischemia can not only reduce injury,but also lay a basic for further studying the role of hamartin and its DNA methylation in other pathophysiological processes and provide theoretical guidance for the following clinical study.In this paper,we review the structure,mechanism and role of hamartin and the effect of its DNA methylation on hypoxia/ischemia.
