Expression Pattern of KLF4 in Korean Gastric Cancers.
10.5230/jkgca.2005.5.3.200
- Author:
Jae Hwi SONG
1
;
Yong Gu CHO
;
Chang Jae KIM
;
Cho Hyun PARK
;
Su Young KIM
;
Suk Woo NAM
;
Sug Hyung LEE
;
Nam Jin YOO
;
Jung Young LEE
;
Won Sang PARK
Author Information
1. Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. wonsang@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Kruppel-like factor;
Zinc finger protein;
Apoptosis;
Tumor suppressor;
Immunohistochemistry
- MeSH:
Apoptosis;
Cytoplasm;
Epithelial Cells;
Gastric Mucosa;
Homeostasis;
Humans;
Immunohistochemistry;
Lymph Nodes;
Neoplasm Metastasis;
Stomach Neoplasms*;
Zinc Fingers
- From:Journal of the Korean Gastric Cancer Association
2005;5(3):200-205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: KLF4, a member of the KLF family, is a zinc finger tumor suppressor protein that is critical for gastric epithelial homeostasis. Our aim was to determine whether the altered expression of KLF4 might be associated with gastric cancer development and, if so, to determine to which pathologic parameter it is linked. MATERIALS AND METHODS: For the construction of the gastric cancer tissue microarray, 84 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of KLF4 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. RESULTS: The KLF4 protein was expressed in cytoplasm and nucleus of superficial and foveolar epithelial cells in the normal gastric mucosa. We found markedly reduced or loss of KLF4 expression in 43 (51.2%) of the 84 gastric cancer tissues. There was no significant correlation between KLF4 expression and pathologic parameters, including histologic type, depth of invasion, lymph node metastasis and peritoneal dissemination. CONCLUSION: Our findings suggest that altered expression of KLF4 may contribute to abnormal regulation of gastrointestinal epithelial cell growth and differentiation and to the development of Korean gastric cancer, as an early event.
