Comparison of RPR′s performance in syphilis screening between pregnant women and non-pregnant women
10.3969/j.issn.1673-4130.2017.10.012
- VernacularTitle:快速血浆反应素试验在妊娠和非妊娠妇女梅毒筛查中的性能比较
- Author:
Weiguo YIN
;
Cuizhen LIU
;
Helin ZHANG
;
Jun LUO
;
Xiaoyun HUANG
;
Chengjin HU
- Keywords:
syphilis;
pregnancy;
rapid plasma reagin;
treponema pallidum particle assay
- From:
International Journal of Laboratory Medicine
2017;38(10):1322-1323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study comparatively the performance of rapid plasma reagin (RPR) test in syphilis detection among pregnant women and non-pregnant women to provide reference for detecting syphilis in pregnant women.Methods The women aged 20-40 years old were selected and divided into the pregnant group and the non-pregnant group.RPR and treponema pallidum particle assay(TPPA) were simultaneously adopted to conduct the syphilis detection.The positive cases were judged by the TPPA detection results combined with the contact history,clinical symptoms and treatment situation.The results were compared with those by RPR for determining the false negative and false positive in RPR.The false negative rate and false positive rate of RPR detection results were analyzed in the two groups.Results Among 117 pregnant women,15 cases were false negative in RPR and 9 cases were false positive in RPR;among 755 non-pregnant women,there were 44 cases of false negative RPR results and 8 cases of false positive RPR results.The false negative rates in the pregnant group and non-pregnant group were 25.0% and 8.8% respectively,the difference was statistically significant(χ2=14.739,P<0.05);the false positive rates in the pregnant group and non-pregnant group were 15.7% and 3.1% respectively,the difference was statistically significant (χ2=14.722,P<0.05).Conclusion There are many factors affecting RPR for detection syphilis,pregnant women are the specific group,so higher false positive rate and false negative rate exist than non-pregnant women,the detection results should be comprehensively judged by combining with clinical symptoms and disease history,if necessary,combining with other syphilis detection method for avoiding missed diagnosis and misdiagnosis.
