Relationship between Autophagy Abnormalities and Pathogenesis of Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2017.05.011
- VernacularTitle:自噬异常与炎症性肠病发病的关系
- Author:
Yangda SONG
;
Yingqiang ZHONG
- Keywords:
Autophagy;
Inflammatory Bowel Disease;
Polymorphisms;
Single Nucleotide;
Immune
- From:
Chinese Journal of Gastroenterology
2017;22(5):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy dysfunction is present in patients with inflammatory bowel disease (IBD), and the single-nucleotide polymorphisms (SNP) of autophagy related genes ATG16L1, NOD2 and IRGM might contribute to an increased susceptibility to IBD.Autophagy might participate in the pathogenesis of IBD through immune response and tolerance, intracellular bacterial infection, abnormalities in immune regulation and Paneth cells, and endoplasmic reticulum stress.This article reviewed the relationship between autophagy abnormalities and pathogenesis of IBD.
