Establishment of chronic myocardial ischemia model in minipigs and application of noninvasive telemetry technique
10.3969.j.issn.1671-7856.2017.05.006
- VernacularTitle:小型猪慢性心肌缺血模型的建立与无创遥测技术的应用
- Author:
Minli CHEN
;
Yongming PAN
;
Liang CHEN
;
Xiaoping XU
;
Dejun WANG
;
Yuwei YANG
;
Fangming CHEN
;
Yueqin CAI
;
Jianqin XU
;
Keyan ZHU
- Keywords:
Minipig;
Chronic myocardial ischemia;
Non-invasive telemetry technique;
Atherosclerosis;
Heart rate variability;
Adaptive recovery period
- From:
Chinese Journal of Comparative Medicine
2017;27(5):16-18
- CountryChina
- Language:Chinese
-
Abstract:
In order to establish the minipig model of chronic myocardial ischemia and apply non-invasive telemetry technique, the minipig model of chronic myocardial ischemia was made induced by Vitamin D3, isoproterenol and combined with high fat diet, and the non-invasive telemetry technique was used to detect and evaluate the symptoms of minipig model of chronic myocardial ischemia.Moreover, the effects of transport stress and the risk factors of atherosclerosis (AS) induced by high fat diet among Wuzhishan minipigs, Bama minipigs and Tibetan minipigs were also evaluated.Our study has successful established the Bama minipig model of chronic myocardial ischemia and the technical specification for evaluation,.The non-invasive telemetry technique can be used to detect and evaluate the symptoms of chronic myocardial ischemia model, and defines minipigs at least need to keep for more than 4 weeks after transport stress to adaptive recovery period.In addition, the different characteristics of AS risk factors such as hyperlipidemia, hypertension and hyperinsulinemia were observed in Wuzhishan minipigs, Bama minipigs and Tibetan minipigs in high fat environment, and this provides a reference for the selection and application of minipigs in the research of cardiovascular diseases.
