Clinical Efficacy and Effects on Inflammatory Factors and Coagulation Function of Prednisone Combined with Aminomethylbenzoic Acid in Patients with Irritability Purpura
- VernacularTitle:泼尼松联合氨甲苯酸对过敏性紫癜患者疗效及对炎症因子和凝血功能的影响观察
- Author:
Ping ZHANG
;
Ming WANG
- Keywords:
Prednisone;
Aminomethylbenzoic acid injecion;
Efficacy;
Inflammatory factors;
Coagulation function
- From:
China Pharmacist
2017;20(5):845-847
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical efficacy of prednisone combined with aminomethylbenzoic acid in the treatment of patients with irritability purpura and its effects on inflammatory factors and coagulation function.Methods: Totally 98 cases of patients with irritability purpura were randomly divided into the observation group (n=49) and the control group (n=49).The control group was treated with prednisone, while the observation group was given aminomethylbenzoic acid injection on the basis of the control group.Both groups were treated for 4 weeks.The efficacy of the two groups was compared, and the changes of serum inflammatory factors and coagulation function before and after the treatment, the disappearance time of stomachache, purpura and arthralgia and adverse drug reactions were also observed and compared.Results: The total effective rate of the observation group (93.88%) was significantly higher than that of the control group (73.47%, P<0.05).After the treatment, the serum level of IL-12 increased, the IL-15 and IL-23 levels decrease, and the D-D dimer and Fib levels decreased in both groups;the serum level of IL-12 in the observation group was higher than that in the control group, and the IL-15 and IL-23 levels were lower than those in the control group (P<0.05);the D-D dimer and Fib levels in the observation group after the treatment were lower than those in the control group (P<0.05).The disappearance time of abdominal pain, purpura and joint pain in the observation group was significantly shorter than that in the control group (P<0.05).ECG, blood and urine routine, liver and kidney function were normal in both groups without serious adverse reactions.Conclusion: Prednisone combined with aminomethylbenzoic acid in the treatment of irritability purpura shows striking effects without obvious adverse reactions, and the actions may be related to reducing the inflammatory reaction and improving coagulation function, which is better than prednisone used alone.
