Characterization of Indomethacin Enteric-coated Dropping Pills
- VernacularTitle:吲哚美辛肠溶滴丸分散状态的表征
- Author:
Jun WANG
;
Xiaohua FANG
;
Yongjun HU
- Keywords:
Indometacin;
Enteric-coated;
Dropping pills;
Characterization
- From:
China Pharmacist
2017;20(5):914-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the status of indomethacin (IDM) in IDM enteric-coated dropping pills and its interaction with PEG 6000.Methods: IDM, PEG 6000, their physical mixture and IDM enteric-coated dropping pills were respectively studied by DSC, IR, X-ray diffraction and SEM.Results: In the map of DSC, the endothermic peak of IDM enteric-coated dropping pills disappeared at 164℃, and the endothermic peak of PEG 6000 at 57℃ shifted forward.In the map of IR, the carbonyl stretching vibration peak of IDM in IDM enteric-coated dropping pills disappeared, and a new peak appeared at 1 680 cm-1.In the map of X-ray diffraction, there was no diffraction peak in IDM enteric-coated dropping pills.SEM showed the morphology of IDM in the base was much smaller than that of IDM raw material.Conclusion: IDM in IDM enteric-coated dropping pills is dispersed in the matrix with an amorphous or molecular form, and there is hydrogen bond between IDM and PEG 6000.
